Once you have installed the program, you will need to create an EndNote library to store your references. If you have an existing library on your computer it may open to this directly. It is recommended that you only create one library.
Your EndNote library consists of two files: a .enl (EndNote library) file and a .Data folder. It is important that both of these remain together in the same location and that they use the same name. Your EndNote library will not work if the data folder is deleted or separated from the .enl file.